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KMID : 1235520170160040156
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Research in Vestibular Science
2017 Volume.16 No. 4 p.156 ~ p.160
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Brain Hypometabolism in Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome
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Jeong Byoung-Min
Shin Byoung-Soo
Seo Man-Wook
Park Ji-Yun
Jeong Hwan-Jeong
Oh Sun-Young
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Abstract
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Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowing progressive ataxic disorder characterized by bilateral vestibulopathy, cerebellar ataxia and somatosensory impairment. Autonomic dysfunction is recently considered as a core feature in CANVAS in addition to these symptoms. In most cases, patients with CANVAS show cerebellar atrophy in brain imaging, but some cases show minimal or no atrophy of cerebellum. Brain (18F)-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) study can be a complimentary tool to diagnosis CANVAS in cases of no structural abnormality such as cerebellar atrophy. Hereby, we present a case of CANVAS with minimal atrophy of cerebellum but showing a prominent hypometabolism in cerebellum, thalamus and posterior cingulate cortex in 18F-FDG PET.
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KEYWORD
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Bilateral vestibulopathy, Cerebellar ataxia, Primary dysautonomias, Positron-emission tomography
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